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For example, a seminal effort cataloged context-specific DDR gene phenotypes by profiling 27 genotoxic agents in a TP53 -null RPE1 cell line using a CRISPR–Cas9 KO screening strategy 43

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The subunit composition of GABA A receptors determines a number of functional factors, including subcellular localization (eg, synaptic versus extrasynaptic localization), channel open probabilities, desensitization rate, and modulatory ligand affinity